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SCHEMBL20133703

SCHEMBL20133703

Cc1cc(C)c(C(=O)O)cc1NC1CCN(c2ccccc2Cl)CC1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MTOR P42345 4/20 0.49
▸ RPTOR Q8N122 4/20 0.49
▸ MLST8 Q9BVC4 4/20 0.49
▸ NOTUM Q6P988 2/20 0.45
▸ GAA P10253 2/20 0.42
▸ L3MBTL1 Q9Y468 2/20 0.42
▸ MALT1 Q9UDY8 2/20 0.42
▸ ALDH1A1 P00352 1/20 0.42
▸ HSP90AA1 P07900 1/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ EHMT2 Q96KQ7 1/20 0.41
▸ KMT2A Q03164 3/20 0.40
▸ MEN1 O00255 2/20 0.40
▸ DRD2 P14416 1/20 0.40
▸ DRD4 P21917 1/20 0.40
▸ DRD3 P35462 1/20 0.40
▸ HRH1 P35367 1/20 0.40
▸ CCR3 P51677 1/20 0.40
▸ KCNH2 Q12809 1/20 0.40
▸ RBP4 P02753 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20133702 0.89 MTOR (0.47) MTORRPTORMLST8NOTUMGAA
SCHEMBL20141082 0.86 MTOR (0.45) MTORRPTORMLST8MALT1ALDH1A1
SCHEMBL20129686 0.86 MTOR (0.49) MTORRPTORMLST8ALDH1A1EHMT2
SCHEMBL20129637 0.86 MTOR (0.64) MTORRPTORMLST8ALDH1A1SMN1; SMN2
SCHEMBL20133698 0.83 ALDH1A1 (0.50) NOTUMALDH1A1SMN1; SMN2KMT2AMEN1
SCHEMBL20133738 0.82 MTOR (0.48) MTORRPTORMLST8GAAKMT2A
SCHEMBL20133590 0.82 MTOR (0.62) MTORRPTORMLST8ALDH1A1KMT2A
SCHEMBL20133751 0.82 MTOR (0.72) MTORRPTORMLST8GAAL3MBTL1
SCHEMBL20150234 0.82 MTOR (0.53) MTORRPTORMLST8NOTUMGAA
SCHEMBL20133753 0.80 MTOR (0.53) MTORRPTORMLST8GAAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2020-11-24 — — US disclosed
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2020-07-02 — — US disclosed
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2019-09-17 — — US disclosed
WO-2018089499-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. (US) 2018-05-17 — — WO disclosed
US-20180127370-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2018-05-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-20180127370-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.