Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 18/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18109747 | 0.95 | DHFR (0.69) | DHFR | |
| SCHEMBL16984491 | 0.90 | DHFR (0.70) | DHFR | |
| SCHEMBL15075240 | 0.83 | DHFR (0.69) | DHFR | |
| SCHEMBL6304549 | 0.80 | DHFR (0.60) | DHFR | |
| Bromide SCHEMBL5861857 | 0.78 | DHFR (0.59) | DHFR | |
| SCHEMBL16980984 | 0.78 | DHFR (0.55) | DHFR | |
| SCHEMBL4564822 | 0.77 | DHFR (0.48) | DHFR | |
| SCHEMBL6310626 | 0.76 | DHFR (0.59) | DHFR | |
| SCHEMBL16980936 | 0.75 | DHFR (0.56) | DHFR | |
| SCHEMBL20780857 | 0.73 | NOS1 (0.67) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321265-A1 | 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS AND THEIR UTILISATION AS MODULATORS OF TOLL-LIKE RECEPTORS | Gilead Sciences, Inc. (US) | 2018-05-16 | — | — | EP | disclosed |