Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 13/20 | 1.00 |
| ▸ | POLB | P06746 | 12/20 | 1.00 |
| ▸ | PKM | P14618 | 11/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 10/20 | 1.00 |
| ▸ | TSHR | P16473 | 8/20 | 1.00 |
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 1.00 |
| ▸ | ESR1 | P03372 | 5/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | PABPC1 | P11940 | 1/20 | 1.00 |
| ▸ | EIF4H | Q15056 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 13/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.81 |
| ▸ | RECQL | P46063 | 4/20 | 0.79 |
| ▸ | HTT | P42858 | 4/20 | 0.79 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013693 | 1.00 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2POLBPKML3MBTL1 | |
| SCHEMBL2020480 | 0.90 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2POLBPKML3MBTL1 | |
| SCHEMBL2014912 | 0.88 | POLB (1.00) | ALDH1A1SMN1; SMN2POLBPKML3MBTL1 | |
| SCHEMBL2016219 | 0.85 | SMN1; SMN2 (0.87) | ALDH1A1SMN1; SMN2POLBPKML3MBTL1 | |
| SCHEMBL2016888 | 0.85 | POLB (0.84) | ALDH1A1SMN1; SMN2POLBPKML3MBTL1 | |
| SCHEMBL2019581 | 0.85 | POLB (1.00) | ALDH1A1SMN1; SMN2POLBPKML3MBTL1 | |
| SCHEMBL2015501 | 0.85 | POLB (1.00) | ALDH1A1SMN1; SMN2POLBPKML3MBTL1 | |
| SCHEMBL2016416 | 0.84 | POLB (0.80) | ALDH1A1SMN1; SMN2POLBPKML3MBTL1 | |
| SCHEMBL2016203 | 0.84 | POLB (1.00) | ALDH1A1SMN1; SMN2POLBPKML3MBTL1 | |
| SCHEMBL2015999 | 0.83 | ALDH1A1 (0.79) | ALDH1A1SMN1; SMN2POLBPKML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073929-A1 | 6-(2-FURYL)-3-METHYL-4-OXO-1,5,6,7-TETRAHYDROINDOLE-2-CARBOXYLATE DERIVATIVES AND USES THEREOF | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073929-A1 | 6-(2-FURYL)-3-METHYL-4-OXO-1,5,6,7-TETRAHYDROINDOLE-2-CARBOXYLATE DERIVATIVES AND USES THEREOF | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2011-06-23 | — | — | WO | disclosed |