Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 4/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138698 | 0.75 | ADORA1 (0.36) | ALKTRPA1MAP4K4MAPK14ADORA1 | |
| SCHEMBL12826223 | 0.62 | MAP4K4 (0.49) | TRPA1MAP4K4MAPK14SOS1CYP1A2 | |
| SCHEMBL24716435 | 0.60 | PTGS1 (0.46) | SOS1FFAR4 | |
| SCHEMBL14901056 | 0.60 | PARP10 (0.55) | FFAR4 | |
| SCHEMBL28811890 | 0.59 | MAP4K4 (0.56) | TRPA1MAP4K4MAPK14SOS1 | |
| SCHEMBL29860742 | 0.59 | MAP4K4 (0.56) | TRPA1MAP4K4MAPK14SOS1 | |
| SCHEMBL29513208 | 0.58 | CA12 (0.50) | CYP1A2 | |
| SCHEMBL254529 | 0.58 | CA12 (0.50) | CYP1A2 | |
| SCHEMBL2298852 | 0.58 | PARP10 (0.49) | FFAR4 | |
| SCHEMBL4336604 | 0.58 | SOS1 (0.56) | SOS1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538516-A1 | PHENOXYTRIAZOLES | F. Hoffmann-La Roche AG (CH) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018087018-A1 | PHENOXYTRIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-05-17 | — | — | WO | disclosed |