Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 5/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | BAX | Q07812 | 1/20 | 0.48 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077805 | 0.81 | LTA4H (0.54) | SOS1LTA4HTSHRMAOBMAOA | |
| SCHEMBL16792619 | 0.81 | MAOA (0.54) | SOS1LTA4HTSHRMAOBMAOA | |
| SCHEMBL7420394 | 0.81 | LTA4H (0.48) | SOS1LTA4HTSHRSLC6A4MAOB | |
| SCHEMBL11392352 | 0.81 | LTA4H (0.48) | LTA4HTSHRHTR2ASLC6A4MAOB | |
| SCHEMBL30127396 | 0.81 | MAOA (0.54) | SOS1LTA4HTSHRMAOBMAOA | |
| SCHEMBL14662201 | 0.81 | SOS1 (0.60) | SOS1LTA4HTSHRHTR2ASLC6A4 | |
| SCHEMBL28759207 | 0.81 | LTA4H (0.48) | SOS1LTA4HTSHRMAOBMAOA | |
| SCHEMBL17064421 | 0.81 | MAOA (0.54) | SOS1LTA4HTSHRMAOBMAOA | |
| SCHEMBL20511766 | 0.81 | LTA4H (0.48) | SOS1LTA4HTSHRMAOBMAOA | |
| SCHEMBL29525311 | 0.81 | MAOA (0.54) | SOS1LTA4HTSHRMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080098-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. Hoffmann-La Roche AG (CH) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015086636-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-18 | — | — | WO | disclosed |
| US-20090023075-A1 | Nonaqueous electrolyte including Diphenyl ether and lithium secondary battery using thereof | PANAX ETEC CO., LTD (KR) | 2009-01-22 | — | — | US | disclosed |