Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154110 | 1.00 | GBA1 (0.35) | GBA1POLBHDAC6HDAC8DYRK2 | |
| SCHEMBL30235143 | 1.00 | GBA1 (0.35) | GBA1POLBHDAC6HDAC8DYRK2 | |
| SCHEMBL20139161 | 0.88 | POLB (0.30) | POLBHDAC6HDAC8 | |
| SCHEMBL20139182 | 0.88 | POLB (0.30) | POLBHDAC6HDAC8 | |
| SCHEMBL30234844 | 0.88 | GPR119 (0.41) | GBA1POLBUSP30MEN1KMT2A | |
| SCHEMBL20154071 | 0.88 | GPR119 (0.41) | GBA1POLBUSP30MEN1KMT2A | |
| SCHEMBL20154258 | 0.86 | POLB (0.33) | POLBHDAC6HDAC8DYRK2MET | |
| SCHEMBL20138947 | 0.86 | POLB (0.33) | POLBHDAC6HDAC8DYRK2MET | |
| SCHEMBL20138766 | 0.83 | GBA1 (0.38) | GBA1POLBHDAC6HDAC8DYRK2 | |
| SCHEMBL23369067 | 0.82 | GBA1 (0.47) | GBA1POLBMETMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538523-A1 | PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS | Cancer Research Technology Limited (GB) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018087527-A1 | PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-05-17 | — | — | WO | disclosed |