Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 2/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.31 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138947 | 1.00 | POLB (0.33) | POLBUSP30CNR1PRKCQPARP1 | |
| SCHEMBL20154097 | 0.89 | GPR119 (0.39) | POLBUSP30GPR119 | |
| SCHEMBL20138763 | 0.87 | — | — | |
| SCHEMBL20154091 | 0.87 | POLB (0.33) | POLBUSP30CNR1PRKCQPARP1 | |
| SCHEMBL30235143 | 0.86 | GBA1 (0.35) | POLBUSP30HDAC8HDAC6GPR119 | |
| SCHEMBL20154110 | 0.86 | GBA1 (0.35) | POLBUSP30HDAC8HDAC6GPR119 | |
| SCHEMBL20138784 | 0.86 | GBA1 (0.35) | POLBUSP30HDAC8HDAC6GPR119 | |
| SCHEMBL20154098 | 0.83 | KIT (0.40) | POLBCNR1GPR119MET | |
| SCHEMBL20143003 | 0.83 | POLB (0.34) | POLBCNR1PARP1PARP2HPGDS | |
| SCHEMBL20139161 | 0.79 | POLB (0.30) | POLBHDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538523-A1 | PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS | Cancer Research Technology Limited (GB) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018087527-A1 | PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-05-17 | — | — | WO | disclosed |