Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 6/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2017156 | 0.85 | TOP1 (0.44) | TOP1NPC1ALDH1A1PDE10APOLB | |
| SCHEMBL1989337 | 0.82 | TOP1 (0.46) | TOP1NPC1ALDH1A1PDE10AKDM4E | |
| SCHEMBL28280373 | 0.76 | FGFR1 (0.55) | TOP1NPC1ALDH1A1TLR9ATM | |
| SCHEMBL5303659 | 0.76 | HRH1 (0.46) | TOP1ALDH1A1BACE1HRH1KDM4E | |
| Hydrochloric Acid SCHEMBL30546241 | 0.74 | TP53 (0.46) | TOP1ALDH1A1BACE1HRH1KDM4E | |
| SCHEMBL28083091 | 0.74 | TOP1 (0.51) | TOP1NPC1ALDH1A1PDE10ATLR9 | |
| Hydrochloric Acid SCHEMBL3841551 | 0.74 | TP53 (0.46) | TOP1ALDH1A1BACE1HRH1KDM4E | |
| SCHEMBL1349852 | 0.73 | AKT1 (0.48) | TOP1NPC1ALDH1A1KDM4ETP53 | |
| SCHEMBL2899383 | 0.73 | TOP1 (0.50) | TOP1NPC1ALDH1A1BACE1PDE10A | |
| SCHEMBL1993651 | 0.73 | TOP1 (0.50) | TOP1NPC1ALDH1A1PDE10AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513109-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075628-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-06-23 | — | — | WO | disclosed |