Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 7/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013910 | 0.85 | TOP1 (0.44) | TOP1NPC1ALDH1A1PDE10APOLB | |
| SCHEMBL1989337 | 0.82 | TOP1 (0.46) | TOP1NPC1ALDH1A1PDE10APOLB | |
| SCHEMBL28083091 | 0.74 | TOP1 (0.51) | TOP1NPC1ALDH1A1PDE10AAKT1 | |
| SCHEMBL1993651 | 0.73 | TOP1 (0.50) | TOP1NPC1ALDH1A1PDE10APOLB | |
| SCHEMBL2899383 | 0.73 | TOP1 (0.50) | TOP1NPC1ALDH1A1PDE10APOLB | |
| SCHEMBL28280373 | 0.73 | FGFR1 (0.55) | TOP1NPC1ALDH1A1RAB9A | |
| SCHEMBL10562956 | 0.73 | MAPT (0.48) | NPC1ALDH1A1PDE10AERBB2POLB | |
| SCHEMBL1989669 | 0.71 | TOP1 (0.44) | TOP1NPC1ALDH1A1PDE10APOLB | |
| SCHEMBL30594669 | 0.69 | CDK5 (0.48) | TOP1NPC1ALDH1A1RAB9APIK3CA | |
| SCHEMBL29093014 | 0.69 | CDK5 (0.48) | TOP1NPC1ALDH1A1RAB9APIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513109-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075628-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-06-23 | — | — | WO | disclosed |