Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 9/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 9/20 | 0.41 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | LMNA | P02545 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MPI | P34949 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018198 | 0.94 | METAP2 (0.41) | METAP2HTTNPSR1MAPTLMNA | |
| SCHEMBL2014321 | 0.89 | METAP2 (0.41) | METAP2HTTNPSR1MAPTLMNA | |
| SCHEMBL2012485 | 0.87 | METAP2 (0.41) | METAP2HTTNPSR1MAPTLMNA | |
| SCHEMBL2012631 | 0.87 | MAPT (0.40) | METAP2HTTNPSR1MAPTLMNA | |
| SCHEMBL2014016 | 0.87 | MAPT (0.41) | METAP2HTTNPSR1MAPTLMNA | |
| SCHEMBL2014721 | 0.86 | MAPT (0.44) | METAP2HTTNPSR1MAPTLMNA | |
| SCHEMBL2017442 | 0.86 | SLC40A1 (0.44) | METAP2HTTNPSR1MAPTLMNA | |
| SCHEMBL2017119 | 0.86 | METAP2 (0.42) | METAP2HTTNPSR1MAPTLMNA | |
| SCHEMBL2016552 | 0.85 | METAP2 (0.43) | METAP2HTTNPSR1MAPTLMNA | |
| SCHEMBL2013576 | 0.85 | METAP2 (0.42) | METAP2HTTNPSR1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |