Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | CKS1B | P61024 | 2/20 | 0.46 |
| ▸ | SKP1 | P63208 | 2/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14672159 | 0.84 | GPR119 (0.50) | RBP4GPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL14355788 | 0.80 | GPR119 (0.44) | RBP4GPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL13216759 | 0.79 | RBP4 (0.69) | RBP4GPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL19126563 | 0.79 | MAPT (0.58) | GPR119ALDH1A1LMNAMAPTNAMPT | |
| SCHEMBL17276765 | 0.78 | CKS1B (0.55) | RBP4GPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL2382922 | 0.77 | GAA (0.69) | GPR119SMARCA2SMARCA4PBRM1CKS1B | |
| SCHEMBL30613376 | 0.77 | GAA (0.69) | GPR119SMARCA2SMARCA4PBRM1CKS1B | |
| SCHEMBL3436307 | 0.77 | AKR1C3 (0.57) | GPR119SMARCA2SMARCA4PBRM1CKS1B | |
| SCHEMBL14852499 | 0.77 | MEN1 (0.56) | GPR119SMARCA2SMARCA4PBRM1CKS1B | |
| SCHEMBL30208139 | 0.77 | MEN1 (0.56) | GPR119SMARCA2SMARCA4PBRM1CKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |