Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 11/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 10/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | FAAH | O00519 | 3/20 | 0.47 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17630358 | 0.87 | MAPT (0.67) | ALDH1A1LMNAMAPTSUV39H2 | |
| SCHEMBL17958739 | 0.87 | MAPT (0.67) | ALDH1A1LMNAMAPTSUV39H2 | |
| SCHEMBL5467063 | 0.87 | MAPT (0.67) | ALDH1A1LMNAMAPTSUV39H2 | |
| SCHEMBL5782039 | 0.86 | MAPT (0.47) | NR1H2NR1H3ALDH1A1LMNAMAPT | |
| SCHEMBL20139232 | 0.83 | NR1H2 (0.55) | NR1H2NR1H3MAPTFAAHSUV39H2 | |
| SCHEMBL20141060 | 0.83 | NR1H2 (0.55) | NR1H2NR1H3FAAHSUV39H2 | |
| SCHEMBL30208177 | 0.83 | NR1H2 (0.55) | NR1H2NR1H3MAPTFAAHSUV39H2 | |
| SCHEMBL24794215 | 0.82 | SIRT6 (0.53) | NR1H2NR1H3ALDH1A1LMNAMAPT | |
| SCHEMBL30082698 | 0.82 | SIRT6 (0.53) | NR1H2NR1H3ALDH1A1LMNAMAPT | |
| SCHEMBL24792933 | 0.82 | SIRT6 (0.53) | NR1H2NR1H3ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |