Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 11/20 | 0.55 |
| ▸ | NR1H3 | Q13133 | 10/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 5/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139232 | 0.88 | NR1H2 (0.55) | NR1H2NR1H3FAAHSUV39H2 | |
| SCHEMBL30208177 | 0.88 | NR1H2 (0.55) | NR1H2NR1H3FAAHSUV39H2 | |
| SCHEMBL16580717 | 0.86 | MAP4K4 (0.55) | NR1H2NR1H3MAP4K4FAAHHDAC1 | |
| SCHEMBL17958723 | 0.86 | MAP4K4 (0.55) | NR1H2NR1H3MAP4K4FAAHHDAC1 | |
| SCHEMBL5465391 | 0.86 | MAP4K4 (0.55) | NR1H2NR1H3MAP4K4FAAHHDAC1 | |
| SCHEMBL20139199 | 0.86 | FAAH (0.56) | NR1H2NR1H3MAP4K4FAAHHDAC1 | |
| SCHEMBL15819221 | 0.86 | FAAH (0.56) | NR1H2NR1H3MAP4K4FAAHHDAC1 | |
| SCHEMBL16933542 | 0.86 | NR1H2 (0.57) | NR1H2NR1H3MAP4K4FAAHHDAC1 | |
| SCHEMBL20159043 | 0.84 | CHRM2 (0.53) | NR1H2NR1H3MAP4K4FAAHSUV39H2 | |
| SCHEMBL5782035 | 0.84 | GPR119 (0.46) | NR1H2NR1H3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |