Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2054334 | 1.00 | HCRTR1 (0.43) | HCRTR1HCRTR2KDM4ELMNAMAOB | |
| SCHEMBL2013932 | 0.89 | KMT2A (0.40) | HCRTR1HCRTR2KDM4ELMNAMAOB | |
| SCHEMBL2053123 | 0.89 | KMT2A (0.40) | HCRTR1HCRTR2KDM4ELMNAMAOB | |
| SCHEMBL2013146 | 0.81 | HCRTR1 (0.66) | HCRTR1HCRTR2MAOBKMT2APTGDR2 | |
| SCHEMBL2051392 | 0.81 | HCRTR1 (0.66) | HCRTR1HCRTR2MAOBKMT2APTGDR2 | |
| SCHEMBL2016670 | 0.80 | HCRTR1 (0.40) | HCRTR1HCRTR2KDM4ELMNAMAOB | |
| SCHEMBL6918283 | 0.80 | HCRTR1 (0.40) | HCRTR1HCRTR2KDM4ELMNAMAOB | |
| SCHEMBL2014119 | 0.80 | HCRTR1 (0.59) | HCRTR1HCRTR2MAOBKMT2ANPC1 | |
| SCHEMBL6919529 | 0.79 | EPHX2 (0.44) | HCRTR1HCRTR2KMT2AMEN1ALDH1A1 | |
| SCHEMBL2012479 | 0.79 | EPHX2 (0.44) | HCRTR1HCRTR2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |