Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.42 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139495 | 0.83 | HTR2A (0.42) | HTR2AHTR2CSLC5A1SLC5A2SLC6A4 | |
| SCHEMBL20140091 | 0.83 | SLC5A1 (0.42) | HTR2AHTR2CSLC5A1SLC5A2SLC6A4 | |
| SCHEMBL20139491 | 0.83 | HTR2A (0.45) | HTR2AHTR2CSLC5A1SLC5A2HRH3 | |
| SCHEMBL20139411 | 0.82 | CHRNA7 (0.47) | HTR2AHTR2CSLC5A1SLC5A2HRH3 | |
| SCHEMBL20141555 | 0.82 | HTR2A (0.44) | HTR2AHTR2CSLC5A1SLC5A2HRH3 | |
| SCHEMBL20140059 | 0.80 | HTR2A (0.43) | HTR2AHTR2CHRH3CYP2D6MEN1 | |
| SCHEMBL20139443 | 0.80 | RAB9A (0.48) | HTR2AHTR2CSLC6A4HRH3CHRNA7 | |
| SCHEMBL20139395 | 0.78 | HTR2A (0.39) | HTR2AHTR2CSLC5A1SLC5A2SLC6A4 | |
| SCHEMBL20141585 | 0.77 | HTR2A (0.42) | HTR2AHTR2CSLC6A4HTR1ASLC6A2 | |
| SCHEMBL21697640 | 0.75 | AGXT (0.40) | HTR2AHTR2CSLC5A1SLC5A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10815210-B2 | Benzocyclobutane derivatives useful as dual SGLT1 / SGLT2 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2020-10-27 | — | — | US | disclosed |
| WO-2018089449-A1 | BENZOCYCLOBUTANE DERIVATIVES USEFUL AS DUAL SGLT1/SGLT2 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10815210-B2 | Benzocyclobutane derivatives useful as dual SGLT1 / SGLT2 modulators | SLC5A2, SLC5A1, SLC2A2 | HTR2A 862/4885HTR2C 879/4885SLC5A1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.