Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGXT | P21549 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 4/20 | 0.35 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16020849 | 0.84 | CYP2A6 (0.36) | AGXTSLC6A4CHRNA7SLC5A2SLC5A1 | |
| SCHEMBL21697633 | 0.83 | SLC5A2 (0.40) | AGXTHTR2AHTR2CSLC6A3SLC5A2 | |
| SCHEMBL20741882 | 0.83 | CYP2A6 (0.40) | AGXTHTR2AHTR2CPTPN1CCR5 | |
| SCHEMBL21697598 | 0.83 | SLC5A2 (0.42) | AGXTSLC5A2SLC5A1ADRA1DPTGER1 | |
| SCHEMBL20741835 | 0.82 | SLC5A2 (0.44) | AGXTPTPN1SLC5A2SLC5A1MEN1 | |
| SCHEMBL16018645 | 0.79 | CYP2A6 (0.43) | AGXTCHRNA7SLC5A2SLC5A1ADRA1D | |
| SCHEMBL21697645 | 0.79 | HTR2A (0.37) | HTR2AHTR2CHTR1ASLC6A2SLC6A4 | |
| SCHEMBL21697625 | 0.78 | AGXT (0.36) | AGXTHTR2AHTR2CPTPN1SLC5A2 | |
| SCHEMBL20139432 | 0.75 | HTR2A (0.45) | HTR2AHTR2CHTR1ASLC6A2SLC6A4 | |
| SCHEMBL21697653 | 0.74 | CYP2A6 (0.40) | AGXTCHRNA7SLC5A2ADRA1DADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968258-B1 | DUAL SGLT1/SGLT2 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-02-12 | — | — | EP | disclosed |