Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139629 | 1.00 | RORC (1.00) | RORCCYP3A4CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL16033505 | 0.91 | RORC (0.83) | RORCCYP3A4CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL20141807 | 0.83 | RORC (0.71) | RORCKMT2AMEN1 | |
| SCHEMBL20139670 | 0.83 | RORC (0.71) | RORCKMT2AMEN1 | |
| SCHEMBL6998474 | 0.82 | RORC (0.68) | RORCCYP3A4CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL2197505 | 0.81 | RORC (0.68) | RORCCHRM2CHRM3 | |
| SCHEMBL4022773 | 0.79 | RORC (0.64) | RORCCYP3A4CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL4772415 | 0.79 | RORC (0.64) | RORCCYP3A4CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL12303485 | 0.78 | RORC (0.64) | RORCSIGMAR1 | |
| SCHEMBL1752470 | 0.78 | RORC (0.64) | RORCSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538522-A1 | ROR GAMMA MODULATORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089406-A1 | ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |