Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.63 |
| ▸ | NPC1 | O15118 | 7/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.63 |
| ▸ | TP53 | P04637 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.58 |
| ▸ | SPR | P35270 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17891160 | 1.00 | RAB9A (0.63) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL21425067 | 0.92 | ALDH1A1 (0.59) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL21138878 | 0.92 | ALDH1A1 (0.59) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL21424973 | 0.92 | ALDH1A1 (0.59) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL1193744 | 0.89 | KCNH2 (0.56) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL3183827 | 0.86 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL3183837 | 0.86 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL27842786 | 0.86 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL3184817 | 0.86 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL29693543 | 0.83 | RAB9A (0.60) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538522-A1 | ROR GAMMA MODULATORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089406-A1 | ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |