Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | AR | P10275 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140806 | 0.87 | NR1H2 (0.46) | NR1H2NR1H3GRM1MAP4K4MAPT | |
| SCHEMBL20157102 | 0.84 | CHRM2 (0.52) | NR1H2NR1H3GRM1MAP4K4MAPT | |
| SCHEMBL20159138 | 0.83 | GPR119 (0.48) | NR1H2NR1H3FFAR4MAPTALDH1A1 | |
| SCHEMBL1902481 | 0.83 | MAPT (0.48) | MAP4K4MAPTALDH1A1LMNAHSD11B1 | |
| SCHEMBL16993954 | 0.82 | MAP4K4 (0.50) | NR1H2NR1H3MAP4K4MAPTALDH1A1 | |
| SCHEMBL30172723 | 0.82 | MAP4K4 (0.50) | NR1H2NR1H3MAP4K4MAPTALDH1A1 | |
| SCHEMBL29767485 | 0.81 | CHRM4 (0.53) | MAP4K4MAPTALDH1A1LMNAHSD11B1 | |
| SCHEMBL30046249 | 0.81 | NR1H2 (0.55) | NR1H2NR1H3MAP4K4CHRM2 | |
| SCHEMBL12778144 | 0.81 | NR1H2 (0.49) | NR1H2NR1H3GPR119AR | |
| SCHEMBL23172489 | 0.80 | AR (0.58) | NR1H2NR1H3ARCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |