Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.42 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.42 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139352 | 0.79 | MTOR (0.41) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20159096 | 0.76 | MTOR (0.60) | MTORRPTORMLST8DRD2HTR7 | |
| SCHEMBL20159082 | 0.71 | MTOR (0.75) | MTORRPTORMLST8DRD3DRD2 | |
| SCHEMBL20140555 | 0.69 | MTOR (0.78) | MTORRPTORMLST8DRD3DRD2 | |
| SCHEMBL20159141 | 0.68 | MTOR (0.64) | MTORRPTORMLST8DRD2ALDH1A1 | |
| SCHEMBL20159090 | 0.67 | MTOR (0.71) | MTORRPTORMLST8DRD3DRD2 | |
| SCHEMBL20139236 | 0.67 | MTOR (0.68) | MTORRPTORMLST8ALDH1A1HTR1A | |
| SCHEMBL20159030 | 0.67 | MTOR (0.62) | MTORRPTORMLST8DRD2ALDH1A1 | |
| SCHEMBL20158992 | 0.67 | MTOR (0.84) | MTORRPTORMLST8DRD3DRD2 | |
| SCHEMBL20159033 | 0.67 | MTOR (0.57) | MTORRPTORMLST8HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |