Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.41 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154262 | 0.84 | MTOR (0.48) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20139831 | 0.79 | MTOR (0.42) | MTORRPTORMLST8HTR1AHTR1D | |
| SCHEMBL20159096 | 0.75 | MTOR (0.60) | MTORRPTORMLST8MAPTLMNA | |
| SCHEMBL20141640 | 0.74 | HTR1A (0.40) | HTR1AMAPTLMNAHTR7 | |
| SCHEMBL20142546 | 0.72 | MTOR (0.40) | MTORRPTORMLST8HTR1AALDH1A1 | |
| SCHEMBL20142371 | 0.72 | MTOR (0.40) | MTORRPTORMLST8HTR1AALDH1A1 | |
| SCHEMBL20142226 | 0.70 | BRPF1 (0.35) | ALDH1A1LMNAMEN1KMT2AGAA | |
| SCHEMBL20157121 | 0.70 | CHRM1 (0.41) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20159082 | 0.69 | MTOR (0.75) | MTORRPTORMLST8HTR1AHTR1D | |
| SCHEMBL20157154 | 0.69 | MTOR (0.45) | MTORRPTORMLST8HTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |