Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.48 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.48 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140695 | 0.82 | MTOR (0.51) | MTORRPTORMLST8THRBNAMPT | |
| SCHEMBL20140200 | 0.81 | MTOR (0.59) | MTORRPTORMLST8THRBNAMPT | |
| SCHEMBL20140798 | 0.80 | MTOR (0.57) | MTORRPTORMLST8THRBNAMPT | |
| SCHEMBL20156802 | 0.80 | MTOR (0.57) | MTORRPTORMLST8THRBNAMPT | |
| SCHEMBL20140753 | 0.80 | MTOR (0.52) | MTORRPTORMLST8NAMPTDRD4 | |
| SCHEMBL20141464 | 0.80 | MTOR (0.56) | MTORRPTORMLST8NAMPTDRD4 | |
| SCHEMBL20140027 | 0.79 | MTOR (0.44) | MTORRPTORMLST8THRBNAMPT | |
| SCHEMBL20141553 | 0.79 | DRD2 (0.57) | MTORRPTORMLST8THRBDRD4 | |
| SCHEMBL20156918 | 0.78 | MTOR (0.55) | MTORRPTORMLST8NAMPTDRD4 | |
| SCHEMBL20139962 | 0.78 | MTOR (0.55) | MTORRPTORMLST8NAMPTDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |