Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 3/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 6/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140035 | 0.90 | GRM1 (0.52) | GRM1CHRM1SLC6A9CHRM4P2RX7 | |
| SCHEMBL26127206 | 0.88 | PARP1 (0.50) | GRM1CHRM1CHRM4PARP1PARP2 | |
| SCHEMBL30546328 | 0.88 | PARP1 (0.50) | GRM1CHRM1CHRM4PARP1PARP2 | |
| SCHEMBL20157095 | 0.83 | GRM1 (0.53) | GRM1CHRM1SLC6A9CHRM4PARP1 | |
| SCHEMBL20140053 | 0.83 | GRM1 (0.53) | GRM1CHRM1SLC6A9CHRM4PARP1 | |
| SCHEMBL20157096 | 0.83 | GRM1 (0.53) | GRM1CHRM1SLC6A9CHRM4PARP1 | |
| SCHEMBL20141517 | 0.74 | KDM4E (0.49) | — | |
| SCHEMBL20140218 | 0.74 | CHRM4 (0.50) | GRM1CHRM1CHRM4PARP1 | |
| SCHEMBL20156960 | 0.74 | CHRM4 (0.50) | GRM1CHRM1CHRM4PARP1 | |
| SCHEMBL20141104 | 0.74 | CHRM1 (0.46) | GRM1CHRM1SLC6A9CHRM4PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |