Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.55 |
| ▸ | RXRA | P19793 | 1/20 | 0.53 |
| ▸ | RXRB | P28702 | 1/20 | 0.53 |
| ▸ | RXRG | P48443 | 1/20 | 0.53 |
| ▸ | LIPE | Q05469 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 4/20 | 0.50 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2896277 | 0.88 | MAPT (0.64) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL265584 | 0.84 | MAPK1 (0.70) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL29874217 | 0.84 | MAPK1 (0.70) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL2880443 | 0.83 | MAPT (0.81) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL19612388 | 0.81 | L3MBTL1 (0.67) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL26132599 | 0.81 | MAPT (0.51) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL19612191 | 0.80 | MAPT (1.00) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL23883421 | 0.80 | MAPT (0.55) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL8497192 | 0.80 | MAPT (0.65) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL23294813 | 0.80 | APP (0.62) | MAPTMAPK1TDP1L3MBTL1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10815210-B2 | Benzocyclobutane derivatives useful as dual SGLT1 / SGLT2 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2020-10-27 | — | — | US | disclosed |
| WO-2018089449-A1 | BENZOCYCLOBUTANE DERIVATIVES USEFUL AS DUAL SGLT1/SGLT2 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10815210-B2 | Benzocyclobutane derivatives useful as dual SGLT1 / SGLT2 modulators | SLC5A2, SLC5A1, SLC2A2 | MAPT 1495/4885MAPK1 1584/4885TDP1 4340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.