Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.54 |
| ▸ | DRD4 | P21917 | 7/20 | 0.54 |
| ▸ | DRD2 | P14416 | 6/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140921 | 0.86 | HTR1A (0.45) | HTR1ADRD4DRD2KCNH2USP2 | |
| SCHEMBL29924281 | 0.84 | ALDH1A1 (0.45) | HTR1ADRD4DRD2KCNH2ALDH1A1 | |
| SCHEMBL29668566 | 0.83 | ALDH1A1 (0.41) | HTR1ADRD4DRD2KCNH2HPGD | |
| SCHEMBL439379 | 0.83 | ALDH1A1 (0.41) | HTR1ADRD4DRD2KCNH2LMNA | |
| SCHEMBL29924612 | 0.83 | ALDH1A1 (0.41) | HTR1ADRD4DRD2KCNH2LMNA | |
| SCHEMBL16422282 | 0.83 | ALDH1A1 (0.41) | HTR1ADRD4DRD2KCNH2LMNA | |
| SCHEMBL14761667 | 0.83 | ALDH1A1 (0.42) | HTR1ADRD4DRD2KCNH2LMNA | |
| SCHEMBL26117408 | 0.83 | HTR1A (0.48) | HTR1ADRD4DRD2KCNH2ALDH1A1 | |
| SCHEMBL16422799 | 0.83 | GRM1 (0.41) | HTR1ADRD4DRD2KCNH2ALDH1A1 | |
| SCHEMBL16544582 | 0.82 | GRM5 (0.59) | HTR1ADRD4DRD2GRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |