Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.41 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | HTT | P42858 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141545 | 0.93 | MTOR (0.49) | MTORRPTORMLST8ALDH1A1HTT | |
| SCHEMBL20140317 | 0.93 | MTOR (0.49) | MTORRPTORMLST8ALDH1A1HTT | |
| SCHEMBL20156838 | 0.88 | ALDH1A1 (0.39) | MTORRPTORMLST8ALDH1A1HTT | |
| SCHEMBL20140350 | 0.86 | MTOR (0.54) | MTORRPTORMLST8ALDH1A1HTT | |
| SCHEMBL20140679 | 0.81 | MTOR (0.51) | MTORRPTORMLST8ALDH1A1HTT | |
| SCHEMBL20140926 | 0.81 | MTOR (0.54) | MTORRPTORMLST8ALDH1A1HTT | |
| SCHEMBL20141003 | 0.81 | MTOR (0.54) | MTORRPTORMLST8ALDH1A1HTT | |
| SCHEMBL20141543 | 0.81 | MTOR (0.54) | MTORRPTORMLST8ALDH1A1HTT | |
| SCHEMBL20140200 | 0.80 | MTOR (0.59) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20141465 | 0.78 | PARP1 (0.49) | MTORRPTORMLST8ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |