Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19527540 | 0.78 | KDM4E (0.44) | GRM5CHRM4DRD2KDM4EALDH1A1 | |
| SCHEMBL6132771 | 0.76 | KDM4E (0.50) | KDM4ECYP3A4 | |
| SCHEMBL13176022 | 0.76 | MEN1 (0.59) | GRM5DRD2KDM4EALDH1A1HTR7 | |
| SCHEMBL20140119 | 0.76 | GRM5 (0.49) | GRM5CHRM4DRD2KDM4EALDH1A1 | |
| SCHEMBL30619347 | 0.75 | ALDH1A1 (0.62) | GRM5DRD2KDM4EALDH1A1DRD4 | |
| SCHEMBL3088832 | 0.73 | DRD4 (0.54) | GRM5DRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7519811 | 0.72 | CHRM4 (0.45) | GRM5CHRM4DRD2KDM4EALDH1A1 | |
| SCHEMBL2261269 | 0.72 | KDM4E (0.47) | GRM5CHRM4DRD2KDM4EALDH1A1 | |
| SCHEMBL20139850 | 0.72 | KCNMA1 (0.50) | GRM5CHRM4DRD2ALDH1A1DRD4 | |
| SCHEMBL20756875 | 0.72 | KDM4E (0.44) | GRM5CHRM4DRD2ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |