Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.72 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.72 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.72 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140826 | 0.91 | MTOR (0.67) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20158919 | 0.88 | MTOR (0.72) | MTORRPTORMLST8FNTAFNTB | |
| SCHEMBL20140252 | 0.88 | MTOR (0.60) | MTORRPTORMLST8DRD2AOC3 | |
| SCHEMBL20140249 | 0.88 | MTOR (0.60) | MTORRPTORMLST8DRD2AOC3 | |
| SCHEMBL20139510 | 0.85 | MTOR (0.68) | MTORRPTORMLST8FNTAFNTB | |
| SCHEMBL20159146 | 0.85 | MTOR (0.68) | MTORRPTORMLST8FNTAFNTB | |
| SCHEMBL20140306 | 0.85 | MTOR (0.74) | MTORRPTORMLST8CHRM4KDM4E | |
| SCHEMBL20142049 | 0.85 | MTOR (0.71) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20159218 | 0.83 | MTOR (1.00) | MTORRPTORMLST8ALDH1A1DRD2 | |
| SCHEMBL20159231 | 0.83 | MTOR (0.68) | MTORRPTORMLST8ALDH1A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |