Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.74 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.74 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.74 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142049 | 0.92 | MTOR (0.71) | MTORRPTORMLST8AVPR1AKDM4E | |
| SCHEMBL20140826 | 0.91 | MTOR (0.67) | MTORRPTORMLST8AVPR1ATRPA1 | |
| SCHEMBL20142006 | 0.87 | MTOR (0.60) | MTORRPTORMLST8CHRM4MALT1 | |
| SCHEMBL20142009 | 0.87 | MTOR (0.60) | MTORRPTORMLST8CHRM4MALT1 | |
| SCHEMBL20141905 | 0.87 | MTOR (0.63) | MTORRPTORMLST8KDM4ELMNA | |
| SCHEMBL20141008 | 0.85 | MTOR (0.72) | MTORRPTORMLST8AVPR1ATRPA1 | |
| SCHEMBL20159218 | 0.85 | MTOR (1.00) | MTORRPTORMLST8AVPR1AKDM4E | |
| SCHEMBL20159231 | 0.84 | MTOR (0.68) | MTORRPTORMLST8KDM4ELMNA | |
| SCHEMBL20159270 | 0.82 | MTOR (0.57) | MTORRPTORMLST8AVPR1ATRPA1 | |
| SCHEMBL20141800 | 0.82 | MTOR (0.64) | MTORRPTORMLST8AVPR1ATRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |