Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.71 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.71 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140306 | 0.92 | MTOR (0.74) | MTORRPTORMLST8LMNAKDM4E | |
| SCHEMBL20140826 | 0.89 | MTOR (0.67) | MTORRPTORMLST8LMNAKDM4E | |
| SCHEMBL20140502 | 0.87 | MTOR (0.57) | MTORRPTORMLST8LMNAKDM4E | |
| SCHEMBL20140499 | 0.87 | MTOR (0.57) | MTORRPTORMLST8LMNAKDM4E | |
| SCHEMBL20140500 | 0.87 | MTOR (0.67) | MTORRPTORMLST8KDM4EMAPT | |
| SCHEMBL20159231 | 0.86 | MTOR (0.68) | MTORRPTORMLST8LMNAKDM4E | |
| SCHEMBL20141008 | 0.85 | MTOR (0.72) | MTORRPTORMLST8KDM4EKMT2A | |
| SCHEMBL20140534 | 0.83 | MTOR (0.63) | MTORRPTORMLST8MAPTHTT | |
| SCHEMBL20159289 | 0.83 | MTOR (0.63) | MTORRPTORMLST8MAPTHTT | |
| SCHEMBL20141800 | 0.83 | MTOR (0.64) | MTORRPTORMLST8AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |