Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 5/20 | 0.41 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 7/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140914 | 0.92 | MTOR (0.47) | GRM1MTORRPTORMLST8MEN1 | |
| SCHEMBL20156987 | 0.92 | GRM1 (0.43) | GRM1MTORRPTORMLST8MEN1 | |
| SCHEMBL20140823 | 0.89 | MTOR (0.45) | GRM1MTORRPTORMLST8MEN1 | |
| SCHEMBL20140821 | 0.89 | MTOR (0.45) | GRM1MTORRPTORMLST8MEN1 | |
| SCHEMBL20142672 | 0.86 | MTOR (0.50) | GRM1MTORRPTORMLST8NAAA | |
| SCHEMBL20142669 | 0.86 | MTOR (0.50) | GRM1MTORRPTORMLST8NAAA | |
| SCHEMBL20140721 | 0.86 | GRM1 (0.45) | GRM1MTORRPTORMLST8MEN1 | |
| SCHEMBL20157490 | 0.86 | GRM1 (0.45) | GRM1MTORRPTORMLST8MEN1 | |
| SCHEMBL20156885 | 0.84 | MTOR (0.47) | GRM1MTORRPTORMLST8MEN1 | |
| SCHEMBL20142818 | 0.84 | GRM1 (0.45) | GRM1MTORRPTORMLST8NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |