Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 4/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2054410 | 0.83 | TAAR1 (0.42) | TAAR1HTR2AMEN1GAAKMT2A | |
| SCHEMBL2011476 | 0.78 | METAP2 (0.43) | MEN1KMT2ACYP1A2CYP3A4CNR2 | |
| SCHEMBL2011479 | 0.78 | METAP2 (0.43) | MEN1KMT2ACYP1A2CYP3A4CNR2 | |
| SCHEMBL2018027 | 0.74 | HTT (0.38) | TAAR1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL2163965 | 0.74 | MAOB (0.35) | HTR6MAOBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2019128 | 0.73 | METAP2 (0.44) | MEN1KMT2ACYP1A2CYP3A4NFKB1 | |
| SCHEMBL2018508 | 0.73 | KDM4E (0.43) | MEN1KMT2ACYP1A2CYP3A4KDM4E | |
| SCHEMBL2013467 | 0.73 | SMN1; SMN2 (0.41) | MEN1KMT2ACYP1A2CYP3A4KDM4E | |
| SCHEMBL2040390 | 0.72 | MAPT (0.40) | MEN1KMT2AATMCYP1A2GRM2 | |
| SCHEMBL2014589 | 0.72 | METAP2 (0.44) | MEN1KMT2ACYP1A2CYP3A4SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |