Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.35 |
| ▸ | STK3 | Q13188 | 2/20 | 0.35 |
| ▸ | STK4 | Q13043 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2017050 | 0.91 | SLC40A1 (0.40) | HTTLMNAMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2014980 | 0.87 | SLC40A1 (0.38) | HTTLMNAMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2014977 | 0.87 | SLC40A1 (0.38) | HTTLMNAMAPK1SMN1; SMN2L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL2013515 | 0.82 | SLC40A1 (0.36) | HTTLMNASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL2012932 | 0.81 | ABCC1 (0.33) | HTTLMNAMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9953251 | 0.81 | PIK3CD (0.33) | HTTLMNASMN1; SMN2MAPTSTK3 | |
| SCHEMBL2013837 | 0.80 | BTK (0.37) | HTTLMNAMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2013539 | 0.79 | LMNA (0.33) | HTTLMNAMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2013535 | 0.79 | LMNA (0.33) | HTTLMNAMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2015211 | 0.79 | AXL (0.32) | HTTLMNAMAPK1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | claimed |
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |