Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 16/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 15/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.44 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.44 |
| ▸ | ITGB6 | P18564 | 2/20 | 0.44 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21314451 | 1.00 | ITGAV (0.45) | ITGAVITGB3ITGB1ITGA5ITGA2B | |
| SCHEMBL20158363 | 0.89 | ITGB3 (0.37) | ITGAVITGB3ITGB1ITGA5ITGA2B | |
| SCHEMBL30487533 | 0.89 | ITGB3 (0.37) | ITGAVITGB3ITGB1ITGA5ITGA2B | |
| SCHEMBL21314501 | 0.87 | ITGAV (0.42) | ITGAVITGB3ITGB1ITGA5ITGA2B | |
| SCHEMBL20140718 | 0.87 | ITGAV (0.42) | ITGAVITGB3ITGB1ITGA5ITGA2B | |
| SCHEMBL20142245 | 0.83 | ITGAV (0.48) | ITGAVITGB3ITGB1ITGA5ITGA2B | |
| SCHEMBL20158279 | 0.79 | ITGAV (0.71) | ITGAVITGB3ITGB1ITGA5ITGA2B | |
| SCHEMBL20141183 | 0.79 | ITGAV (0.71) | ITGAVITGB3ITGB1ITGA5ITGA2B | |
| SCHEMBL29701391 | 0.79 | ITGAV (0.71) | ITGAVITGB3ITGB1ITGA5ITGA2B | |
| SCHEMBL21314474 | 0.79 | ITGAV (0.46) | ITGAVITGB3ITGB1ITGA5ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538526-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089355-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |