Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 14/20 | 0.37 |
| ▸ | ITGAV | P06756 | 14/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.36 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20158363 | 1.00 | ITGB3 (0.37) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL20140527 | 0.89 | ITGAV (0.45) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL21314451 | 0.89 | ITGAV (0.45) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL23747238 | 0.88 | ITGB3 (0.34) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL20158358 | 0.85 | ITGAV (0.40) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL30487524 | 0.85 | ITGAV (0.40) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL20158360 | 0.81 | ITGAV (0.60) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL30487493 | 0.81 | ITGAV (0.60) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL28744049 | 0.80 | ITGB3 (0.37) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL30487525 | 0.80 | ITGB3 (0.37) | ITGB3ITGAVITGB1ITGA5ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11639353-B2 | Cyclobutanes- and azetidine-containing mono and spirocyclic compounds as αV integrin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11639353-B2 | Cyclobutanes- and azetidine-containing mono and spirocyclic compounds as αV integrin inhibitors | ITGB1, ITGB2, ITGA1 | ITGB3 6/4885ITGAV 4/4885ITGB1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.