Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 3/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.46 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | TACR3 | P29371 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140694 | 0.90 | MTOR (0.50) | SMN1; SMN2TSHRDPP4PARP1MTOR | |
| SCHEMBL20140299 | 0.84 | KDM4E (0.56) | PARP1ALDH1A1KDM4ECFTR | |
| SCHEMBL20139868 | 0.83 | MTOR (0.52) | SMN1; SMN2TSHRMTORRPTORMLST8 | |
| SCHEMBL20139960 | 0.81 | MTOR (0.56) | SMN1; SMN2TSHRDPP4PARP1MTOR | |
| SCHEMBL20157177 | 0.77 | DPP4 (0.48) | TSHRDPP4MTORRPTORMLST8 | |
| SCHEMBL20141188 | 0.77 | MTOR (0.56) | SMN1; SMN2TSHRDPP4PARP1MTOR | |
| SCHEMBL20140642 | 0.77 | MTOR (0.51) | SMN1; SMN2TSHRDPP4PARP1MTOR | |
| SCHEMBL20140808 | 0.74 | MTOR (0.44) | SMN1; SMN2TSHRMTORRPTORMLST8 | |
| SCHEMBL20141464 | 0.74 | MTOR (0.56) | SMN1; SMN2TSHRMTORRPTORMLST8 | |
| SCHEMBL20139883 | 0.74 | MTOR (0.54) | DPP4PARP1MTORRPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |