Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.54 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.54 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.54 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140023 | 0.91 | MTOR (0.61) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20139966 | 0.91 | MTOR (0.61) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20141373 | 0.89 | MTOR (0.49) | MTORRPTORMLST8P2RX7DRD2 | |
| SCHEMBL20140751 | 0.87 | MTOR (0.60) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20141516 | 0.86 | MTOR (0.46) | MTORRPTORMLST8P2RX7KDM4E | |
| SCHEMBL20140818 | 0.85 | P2RX7 (0.46) | MTORRPTORMLST8P2RX7DRD2 | |
| SCHEMBL20140323 | 0.84 | KDM4E (0.54) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20156994 | 0.84 | KDM4E (0.54) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20139945 | 0.84 | MTOR (0.49) | MTORRPTORMLST8P2RX7DRD2 | |
| SCHEMBL20139928 | 0.82 | MTOR (0.56) | MTORRPTORMLST8DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |