Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.35 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.35 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141405 | 0.90 | NOTUM (0.38) | MTORRPTORMLST8SLC6A2SLC6A4 | |
| SCHEMBL20141101 | 0.88 | CHEK1 (0.36) | MTORRPTORMLST8ALDH1A1PLAT | |
| SCHEMBL20141029 | 0.86 | SLC6A2 (0.38) | ALDH1A1PLATCHEK1KCNH2SLC6A2 | |
| SCHEMBL20141030 | 0.83 | SLC6A2 (0.38) | ALDH1A1CHEK1SLC6A2SLC6A4CHEK2 | |
| SCHEMBL20140933 | 0.83 | SLC6A2 (0.36) | ALDH1A1CHEK1SLC6A2SLC6A4CHEK2 | |
| SCHEMBL20141049 | 0.81 | SLC6A2 (0.38) | ALDH1A1CHEK1KCNH2SLC6A2SLC6A4 | |
| SCHEMBL20141038 | 0.80 | KCNH2 (0.37) | ALDH1A1CHEK1KCNH2SLC6A2SLC6A4 | |
| SCHEMBL20141036 | 0.80 | KCNH2 (0.37) | ALDH1A1CHEK1KCNH2SLC6A2SLC6A4 | |
| SCHEMBL20141147 | 0.80 | SLC6A2 (0.38) | ALDH1A1PLATCHEK1KCNH2SLC6A2 | |
| SCHEMBL20141342 | 0.79 | SLC6A2 (0.36) | PLATCHEK1KCNH2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |