Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | DVL1 | O14640 | 1/20 | 0.32 |
| ▸ | DVL3 | Q92997 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.32 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140980 | 0.90 | SLC6A2 (0.36) | NR1I2SLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL20141613 | 0.89 | SLC6A2 (0.38) | SLC6A2SLC6A4DDB1CRBNCCR8 | |
| SCHEMBL20140900 | 0.86 | SLC6A2 (0.41) | SLC6A2SLC6A4DDB1CRBN | |
| SCHEMBL20141029 | 0.82 | SLC6A2 (0.38) | SLC6A2SLC6A4KCNH2HPGDDVL1 | |
| SCHEMBL20141738 | 0.80 | SLC6A2 (0.40) | SLC6A2SLC6A4CCR8KCNH2HPGD | |
| SCHEMBL20141030 | 0.78 | SLC6A2 (0.38) | SLC6A2SLC6A4HPGD | |
| SCHEMBL20141036 | 0.77 | KCNH2 (0.37) | SLC6A2SLC6A4KCNH2HPGDCYP2D6 | |
| SCHEMBL20141038 | 0.77 | KCNH2 (0.37) | SLC6A2SLC6A4KCNH2HPGDCYP2D6 | |
| SCHEMBL20141346 | 0.77 | SLC6A2 (0.44) | SLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL20141147 | 0.77 | SLC6A2 (0.38) | SLC6A2SLC6A4KCNH2HPGDDVL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |