Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.45 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.35 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.35 |
| ▸ | RPS17 | P08708 | 1/20 | 0.35 |
| ▸ | RPSA | P08865 | 1/20 | 0.35 |
| ▸ | RPS2 | P15880 | 1/20 | 0.35 |
| ▸ | RPL35A | P18077 | 1/20 | 0.35 |
| ▸ | RPL7 | P18124 | 1/20 | 0.35 |
| ▸ | RPL17 | P18621 | 1/20 | 0.35 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.35 |
| ▸ | RPS3 | P23396 | 1/20 | 0.35 |
| ▸ | RPS12 | P25398 | 1/20 | 0.35 |
| ▸ | RPL13 | P26373 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140871 | 0.88 | MTOR (0.53) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20140932 | 0.84 | MTOR (0.56) | MTORRPTORMLST8KDM4E | |
| SCHEMBL20133783 | 0.77 | MTOR (0.60) | MTORRPTORMLST8MALT1KCNH2 | |
| SCHEMBL20140981 | 0.75 | MTOR (0.46) | MTORRPTORMLST8AVPR1AKDM4E | |
| SCHEMBL20140935 | 0.74 | MTOR (0.53) | MTORRPTORMLST8KDM4ECCR5 | |
| SCHEMBL22187875 | 0.73 | MTOR (0.57) | MTORRPTORMLST8MALT1KCNH2 | |
| SCHEMBL20141210 | 0.72 | MTOR (0.65) | MTORRPTORMLST8TP53KDM4E | |
| SCHEMBL22188088 | 0.71 | MTOR (0.56) | MTORRPTORMLST8MALT1KCNH2 | |
| SCHEMBL20141509 | 0.70 | MTOR (0.54) | MTORRPTORMLST8MALT1KCNH2 | |
| SCHEMBL20133576 | 0.68 | MTOR (0.75) | MTORRPTORMLST8MALT1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |