Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.53 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.53 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 10/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 9/20 | 0.37 |
| ▸ | PARP3 | Q9Y6F1 | 9/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141210 | 0.91 | MTOR (0.65) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20140932 | 0.91 | MTOR (0.56) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20140981 | 0.82 | MTOR (0.46) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20142302 | 0.81 | MTOR (0.55) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20140929 | 0.80 | MTOR (0.57) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20141245 | 0.77 | SLC6A2 (0.41) | — | |
| SCHEMBL20140846 | 0.74 | SLC6A2 (0.37) | MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL20140871 | 0.74 | MTOR (0.53) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20141035 | 0.74 | MTOR (0.45) | MTORRPTORMLST8KDM4ECCR5 | |
| SCHEMBL20140979 | 0.74 | MTOR (0.46) | MTORRPTORMLST8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |