Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.55 |
| ▸ | RPTOR | Q8N122 | 7/20 | 0.55 |
| ▸ | MLST8 | Q9BVC4 | 7/20 | 0.55 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | PHGDH | O43175 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20149869 | 0.89 | MTOR (0.56) | MTORRPTORMLST8ACHEPHGDH | |
| SCHEMBL20133775 | 0.84 | MTOR (0.53) | MTORRPTORMLST8ACHEPHGDH | |
| SCHEMBL20133773 | 0.84 | MTOR (0.55) | MTORRPTORMLST8ACHEPHGDH | |
| SCHEMBL20133662 | 0.83 | MTOR (0.65) | MTORRPTORMLST8ACHEPHGDH | |
| SCHEMBL20140843 | 0.78 | MTOR (0.44) | MTORRPTORMLST8ACHEPHGDH | |
| SCHEMBL20149898 | 0.76 | MTOR (0.69) | MTORRPTORMLST8PHGDHDRD4 | |
| SCHEMBL20150021 | 0.76 | MTOR (0.70) | MTORRPTORMLST8PHGDHDRD4 | |
| SCHEMBL22187975 | 0.76 | MTOR (0.75) | MTORRPTORMLST8PHGDHGPR6 | |
| SCHEMBL22693272 | 0.75 | MTOR (0.67) | MTORRPTORMLST8PHGDHGPR6 | |
| SCHEMBL22693274 | 0.75 | MTOR (0.67) | MTORRPTORMLST8DRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |