Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.40 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 6/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141109 | 1.00 | MTOR (0.40) | MTORRPTORMLST8GRM1DRD4 | |
| SCHEMBL20142471 | 0.91 | DRD2 (0.42) | MTORRPTORMLST8GRM1DRD4 | |
| SCHEMBL20142472 | 0.91 | DRD2 (0.42) | MTORRPTORMLST8GRM1DRD4 | |
| SCHEMBL20139834 | 0.88 | GRM1 (0.41) | MTORRPTORMLST8GRM1DRD4 | |
| SCHEMBL20140128 | 0.86 | GRM1 (0.45) | MTORRPTORMLST8GRM1DRD4 | |
| SCHEMBL20140839 | 0.82 | POLB (0.46) | MTORRPTORMLST8DRD4DRD2 | |
| SCHEMBL20140644 | 0.80 | GRM1 (0.42) | MTORRPTORMLST8GRM1DRD2 | |
| SCHEMBL20140821 | 0.80 | MTOR (0.45) | MTORRPTORMLST8GRM1DRD4 | |
| SCHEMBL20140823 | 0.80 | MTOR (0.45) | MTORRPTORMLST8GRM1DRD4 | |
| SCHEMBL20140024 | 0.79 | GRM1 (0.43) | GRM1HSD11B1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |