Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 9/20 | 0.68 |
| ▸ | RPTOR | Q8N122 | 9/20 | 0.68 |
| ▸ | MLST8 | Q9BVC4 | 9/20 | 0.68 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20129599 | 0.92 | MTOR (0.66) | MTORRPTORMLST8NAMPTEED | |
| SCHEMBL21340087 | 0.90 | MTOR (0.78) | MTORRPTORMLST8NAMPTEED | |
| SCHEMBL21360359 | 0.88 | MTOR (0.71) | MTORRPTORMLST8NAMPTEED | |
| SCHEMBL20133739 | 0.88 | MTOR (0.78) | MTORRPTORMLST8NAMPTGRM5 | |
| SCHEMBL20149902 | 0.85 | MTOR (0.72) | MTORRPTORMLST8NAMPTGRM5 | |
| SCHEMBL21360385 | 0.85 | MTOR (0.72) | MTORRPTORMLST8NAMPTGRM5 | |
| SCHEMBL20150218 | 0.85 | MTOR (0.74) | MTORRPTORMLST8NAMPTGRM5 | |
| SCHEMBL22187972 | 0.85 | MTOR (0.69) | MTORRPTORMLST8NAMPTEED | |
| SCHEMBL20149875 | 0.84 | MTOR (0.56) | MTORRPTORMLST8NAMPTGRM5 | |
| SCHEMBL20133552 | 0.84 | MTOR (0.66) | MTORRPTORMLST8NAMPTGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |