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SCHEMBL20129599

SCHEMBL20129599

Cc1cc(C)c(C(=O)N2CCN(c3ccccc3S(C)(=O)=NC(=O)OC(C)(C)C)CC2)cc1NC1CCN(c2ccccc2C#N)CC1

nearest known ligand 0.66

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MTOR P42345 8/20 0.66
▸ RPTOR Q8N122 8/20 0.66
▸ MLST8 Q9BVC4 8/20 0.66
▸ EED O75530 1/20 0.37
▸ NAMPT P43490 1/20 0.36
▸ SLC6A9 P48067 3/20 0.35
▸ KCNH2 Q12809 1/20 0.35
▸ P2RY12 Q9H244 1/20 0.35
▸ GRM5 P41594 1/20 0.34
▸ DRD2 P14416 2/20 0.34
▸ DRD4 P21917 1/20 0.34
▸ DRD3 P35462 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ ADRA1D P25100 1/20 0.34
▸ ADRA1A P35348 1/20 0.34
▸ ADRA1B P35368 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20149875 0.93 MTOR (0.56) MTORRPTORMLST8NAMPTP2RY12
SCHEMBL20141237 0.92 MTOR (0.60) MTORRPTORMLST8P2RY12TDP1
SCHEMBL20133534 0.92 MTOR (0.60) MTORRPTORMLST8P2RY12TDP1
SCHEMBL20141219 0.92 MTOR (0.68) MTORRPTORMLST8EEDNAMPT
SCHEMBL20141480 0.90 MTOR (0.78) MTORRPTORMLST8SLC6A9KCNH2
SCHEMBL21340087 0.88 MTOR (0.78) MTORRPTORMLST8EEDNAMPT
SCHEMBL20133710 0.86 MTOR (0.67) MTORRPTORMLST8NAMPTP2RY12
SCHEMBL20133774 0.86 MTOR (0.67) MTORRPTORMLST8NAMPTP2RY12
SCHEMBL21360359 0.86 MTOR (0.71) MTORRPTORMLST8EEDNAMPT
SCHEMBL20149868 0.86 MTOR (0.67) MTORRPTORMLST8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2020-11-24 — — US disclosed
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2020-07-02 — — US disclosed
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2019-09-17 — — US disclosed
US-20180127370-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2018-05-10 — — US disclosed
US-20180127370-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2018-05-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-20180127370-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.