Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.53 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.53 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
| ▸ | ITGAL | P20701 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141156 | 0.91 | MTOR (0.44) | MTORRPTORMLST8HCRTR1HCRTR2 | |
| SCHEMBL20140938 | 0.90 | MTOR (0.63) | MTORRPTORMLST8HCRTR1HCRTR2 | |
| SCHEMBL20140850 | 0.83 | MTOR (0.53) | MTORRPTORMLST8HCRTR1HCRTR2 | |
| SCHEMBL20133648 | 0.77 | MTOR (0.82) | MTORRPTORMLST8HCRTR1HCRTR2 | |
| SCHEMBL20141346 | 0.76 | SLC6A2 (0.44) | SLC6A2SLC6A4 | |
| SCHEMBL20140900 | 0.75 | SLC6A2 (0.41) | SLC6A2SLC6A4 | |
| SCHEMBL20140969 | 0.72 | MTOR (0.43) | MTORRPTORMLST8SLC6A2SLC6A4 | |
| SCHEMBL21340109 | 0.72 | MTOR (0.72) | MTORRPTORMLST8HCRTR1HCRTR2 | |
| SCHEMBL21340108 | 0.72 | MTOR (0.72) | MTORRPTORMLST8HCRTR1HCRTR2 | |
| SCHEMBL20141225 | 0.72 | MTOR (0.41) | MTORRPTORMLST8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |