Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.63 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.63 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.63 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140850 | 0.91 | MTOR (0.53) | MTORRPTORMLST8HCRTR2HCRTR1 | |
| SCHEMBL20141254 | 0.90 | MTOR (0.53) | MTORRPTORMLST8HCRTR2HCRTR1 | |
| SCHEMBL20141156 | 0.82 | MTOR (0.44) | MTORRPTORMLST8HCRTR2HCRTR1 | |
| SCHEMBL20133584 | 0.77 | MTOR (1.00) | MTORRPTORMLST8HCRTR2HCRTR1 | |
| SCHEMBL20140980 | 0.76 | SLC6A2 (0.36) | — | |
| SCHEMBL20141026 | 0.75 | NR1I2 (0.41) | MTORRPTORMLST8 | |
| SCHEMBL20140969 | 0.72 | MTOR (0.43) | MTORRPTORMLST8 | |
| SCHEMBL22159430 | 0.71 | MTOR (0.86) | MTORRPTORMLST8HCRTR2HCRTR1 | |
| SCHEMBL22159431 | 0.71 | MTOR (0.86) | MTORRPTORMLST8HCRTR2HCRTR1 | |
| SCHEMBL20141225 | 0.70 | MTOR (0.41) | MTORRPTORMLST8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |