Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.43 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.43 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | FASN | P49327 | 14/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133840 | 0.89 | MTOR (0.56) | MTORRPTORMLST8FASN | |
| SCHEMBL20133554 | 0.89 | MTOR (0.56) | MTORRPTORMLST8FASN | |
| SCHEMBL20133541 | 0.75 | MTOR (0.64) | MTORRPTORMLST8FASN | |
| SCHEMBL20133555 | 0.75 | MTOR (0.64) | MTORRPTORMLST8FASN | |
| SCHEMBL21360330 | 0.71 | MTOR (0.65) | MTORRPTORMLST8JAK2JAK1 | |
| SCHEMBL20133565 | 0.70 | MTOR (0.81) | MTORRPTORMLST8 | |
| SCHEMBL20133712 | 0.70 | MTOR (0.62) | MTORRPTORMLST8FASN | |
| SCHEMBL20133838 | 0.70 | MTOR (0.62) | MTORRPTORMLST8FASN | |
| SCHEMBL20141739 | 0.69 | MTOR (0.47) | MTORRPTORMLST8JAK2JAK1 | |
| SCHEMBL20140986 | 0.67 | MTOR (0.58) | MTORRPTORMLST8FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |