SCHEMBL20141739 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	MTOR	P42345	6/20	0.47

▸	RPTOR	Q8N122	6/20	0.47

▸	MLST8	Q9BVC4	6/20	0.47

▸	PRKAA2	P54646	2/20	0.40

▸	JAK2	O60674	1/20	0.40

▸	JAK1	P23458	1/20	0.40

▸	JAK3	P52333	1/20	0.40

▸	FASN	P49327	7/20	0.38

▸	SLC6A9	P48067	2/20	0.38

▸	KCNH2	Q12809	2/20	0.38

▸	NOS1	P29475	1/20	0.37

▸	NOS2	P35228	1/20	0.37

▸	EGLN2	Q96KS0	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL20133534	0.90	MTOR (0.60)	MTORRPTORMLST8
SCHEMBL20141237	0.90	MTOR (0.60)	MTORRPTORMLST8
SCHEMBL20129599	0.81	MTOR (0.66)	MTORRPTORMLST8SLC6A9KCNH2
SCHEMBL22693183	0.79	MTOR (0.67)	MTORRPTORMLST8FASN
SCHEMBL20141051	0.79	MTOR (0.70)	MTORRPTORMLST8FASN
SCHEMBL21360393	0.79	MTOR (0.70)	MTORRPTORMLST8FASN
SCHEMBL20133535	0.79	MTOR (0.70)	MTORRPTORMLST8FASN
SCHEMBL21360324	0.77	MTOR (0.76)	MTORRPTORMLST8FASN
SCHEMBL20141480	0.75	MTOR (0.78)	MTORRPTORMLST8SLC6A9KCNH2
SCHEMBL22188088	0.75	MTOR (0.56)	MTORRPTORMLST8KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-3538091-A1	PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF	Navitor Pharmaceuticals, Inc. (US)	2019-09-18	—	—	EP	disclosed
WO-2018089499-A1	PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF	NAVITOR PHARMACEUTICALS, INC. (US)	2018-05-17	—	—	WO	disclosed