Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.78 |
| ▸ | RPTOR | Q8N122 | 8/20 | 0.78 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.78 |
| ▸ | SLC6A9 | P48067 | 7/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20129599 | 0.90 | MTOR (0.66) | MTORRPTORMLST8SLC6A9KCNH2 | |
| SCHEMBL20133729 | 0.88 | MTOR (1.00) | MTORRPTORMLST8SLC6A9KCNH2 | |
| SCHEMBL20133711 | 0.88 | MTOR (1.00) | MTORRPTORMLST8SLC6A9KCNH2 | |
| SCHEMBL20133709 | 0.88 | MTOR (1.00) | MTORRPTORMLST8SLC6A9KCNH2 | |
| SCHEMBL20141306 | 0.86 | MTOR (0.85) | MTORRPTORMLST8MAPTDPP4 | |
| SCHEMBL20141237 | 0.85 | MTOR (0.60) | MTORRPTORMLST8MAPT | |
| SCHEMBL20133534 | 0.85 | MTOR (0.60) | MTORRPTORMLST8MAPT | |
| SCHEMBL21360300 | 0.83 | MTOR (0.78) | MTORRPTORMLST8MAPTDPP4 | |
| SCHEMBL20149875 | 0.83 | MTOR (0.56) | MTORRPTORMLST8DPP4 | |
| SCHEMBL20149868 | 0.82 | MTOR (0.67) | MTORRPTORMLST8TP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |